Synthesis, Characterization, Anti-tubercular Evaluation, and Teratogenicity Studies of Novel 5-(4-fluorobenzoyl) tetrahydro benzamidazoquinazoline Derivatives

Background: The largest infectious agent-related cause of death and the most common disease with a high contagiousness profile is tuberculosis. For treatment tuberculosis, various benzimidazole quinazoline compounds have been developed in past effectiveness. In this example, our goal was to synthesise new enhanced activity by combining moieties quinazoline. present study planned synthesize novel 5-(4-flourobenzoyl)12- (substitutedphenyl)-3,3-dimethyl-3,4,5,12-tetrahydrobenzo [4,5] imidazo [2,1-b] quinazolin-1(2H)-one derivatives. Materials Methods: A series benzamidazo derivatives were synthesized characterized using IR,1 HNMR, 13CNMR, Mass spectroscopy. antitubercular synthesised evaluated against H37RV strain determine their potential. To examine teratogenicity compounds, zebrafish larvae utilised. Results Discussion: At 3.25 µg/ mL, R2, R3, R4 R9 exhibited good efficacy Mycobacterium tuberculosis strains. Most proved as safe at 0.5 µM without any abnormalities. Conclusion: Compounds containing Electron withdrawing groups 4th position found possess excellent